Gentamicin

Gentamicin used for bacterial infection

Table of Contents

Gentamicin is medicine that can help prevent or treat numerous types of bacterial infections. It belongs to a class of aminoglycoside antibiotics – which works by stopping the growth of bacteria.

Gentamicin is available in the form of injections, drops, creams, and ointments. Gentamicin injection drug is useful for preventing or treating various kinds of bacterial infections. It may also be used for other purposes not listed. 

Gentamicin Dosage Considerations 

Do not change the dose without your doctor’s approval. 

Dosage for adults with Osteomyelitis

Systemic infection: 1 mg / kg IM or IV infusion (over 30 to 120 minutes) every 8 hours. The length of the therapy session is 7 to 10 days.

Dosage for adults with Skin or Soft Tissue Infections

Systemic infection: 1 mg / kg IM or IV infusion (over 30 to 120 minutes) every 8 hours. The length of the therapy session is 7 to 10 days.

Dosage for adults with Bacterial Infections

Systemic infection: 1 mg / kg IM or IV infusion (over 30 to 120 minutes) every 8 hours. The length of the therapy session is 7 to 10 days.

Dosage for adults with Urinary Tract Infections (UTIs)

Systemic infection: 1 mg / kg IM or IV infusion (over 30 to 120 minutes) every 8 hours. The length of the therapy session: 7 to 10 days.

Dosage for adults with Sepsis

Systemic infection: 1 mg / kg IM or IV infusion (over 30 to 120 minutes) every 8 hours. The length of the therapy session is 7 to 10 days.

Dosage for adults with Skin Burns – External

Systemic infection: 1 mg / kg IM or IV infusion (over 30 to 120 minutes) every 8 hours. The length of the therapy session is 7 to 10 days.

Dosage for adults with Meningitis

Systemic infection: 1 mg / kg IM or IV infusion (over 30 to 120 minutes) every 8 hours. The length of the therapy session is 7 to 10 days.

Dosage for adults with Pneumonia

Systemic infection: 1 mg / kg IM or IV infusion (over 30 to 120 minutes) every 8 hours. The length of the therapy session is 7 to 10 days.

Guidelines for Gentamicin

Use gentamicin as exactly directed by your doctor. Here’s how to use Gentamicin: 

  • Gentamicin is available in an injectable form. It is also available as a cream and an ointment. If you are taking injectable gentamicin, it is injected into your vein or muscle – as directed by your doctor, usually every 8 hours.
  • The dosage given is based on your medical condition, weight, and response to treatment. Laboratory tests such as kidney function and blood levels may be an option to help determine the suitable dosage for your condition.
  • If you are using this medication for yourself at home, learn all the preparations and directions for use from your doctor. Before using, check this product. If the medicine has discoloration. do not take it. Learn how to store and dispose of the medicine safely. 
  • For optimal results, use these antibiotics at the same time. To keep track of your medication schedule, take it at the same time each day.
  • Continue to take this medication even if symptoms disappear after a few days. Stopping treatment too early may keep bacteria from growing, which can lead to recurrent infections
  • Tell your doctor if your condition does not improve or worsens. 

What is Gentamicin Used for

Gentamicin can be used to prevent or treat a range of bacterial infections. Gentamicin may be used for treatments of: 

  • Sepsis
  • Meningitis
  • Pneumonia
  • Osteomyelitis
  • Bacterial infection
  • Burns (external)
  • Urinary tract infection (UTI)
  • Skin or soft tissue infections.

Contraindications for Gentamicin

Gentamicin may be contraindicated with aminoglycoside toxicity or hypersensitivity. Aminoglycosides are a group of antibiotics that function to treat bacterial infections.

Warnings

Before using gentamicin, pay attention to the following precautions: 

  • Inform your doctor or pharmacist if you are allergic to it or other aminoglycoside antibiotics (such as tobramycin, amikacin) or if you have any other allergies. This product may contain inactive ingredients which can cause allergic reactions or other problems.
  • Tell your doctor or pharmacist about your medical history, especially if you have cystic fibrosis, hearing problems, kidney problems, low blood minerals (including potassium, magnesium, and calcium), myasthenia gravis, or Parkinson’s disease.
  • Gentamicin may cause live bacterial vaccines to not function properly. Do not have any immunizations or vaccinations while using this medicine unless your doctor recommends it.
  • Before having surgery, tell your doctor or dentist about any current medications you are taking, including prescription and nonprescription medications, and herbal products.
  • Older adults may be more sensitive to the effects of this drug, especially kidney damage.
  • This medicine is not recommended for use during pregnancy. Discuss the risks and benefits with your obstetrician.
  • This medicine may pass into breast milk. However, many doctors consider it safe to use for lactating women. It is recommended that you consult your doctor before breastfeeding.

Drug Interactions

Drug interactions can change how medications work or increase the risk of serious side effects. Do not start, stop, or change the dose of any medicine without your doctor’s approval.

Combined use of gentamicin with certain medications may increase the risk of kidney damage or hearing loss.

Other drugs that may interact with gentamicin, such as: 

  • Amikacin
  • Cidofovir
  • Cisplatin
  • Tobramycin
  • Polymyxin B
  • Amphotericin B
  • Cephalosporins, such as cephaloridine
  • Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, and others

List of Gentamicin Side Effects

Below are some of the most common side effects of gentamicin:

  • Nausea, vomiting, abdominal pain, or loss of appetite. Pain, irritation, redness at the injection site may be rare. If any of these effects persist or worsen, tell your doctor or pharmacist immediately.
  • Your doctor prescribed this medication because he or she has judged that the benefits outweigh the risk of side effects. Many people using this medication do not have serious side effects.
  • Tell your doctor right away if you have any serious side effects, such as numbness, tingling, muscle twitching, muscle weakness, or spasms.
  • This medicine may rarely cause a severe intestinal irritation due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrheal or opioid medicines if you experience any of the following symptoms as these products may worsen your condition. Inform your doctor right away if you experience persistent diarrhea, pain, stomach cramps, blood in stools.
  • Use of this medication for long or repeated periods may lead to thrush or a new yeast infection. Contact your doctor if you see white patches in your mouth, abnormal vaginal discharge, or other new symptoms.
  • Very serious allergic reactions to this drug are rare. However, seek prompt medical help if you notice any of the symptoms of a serious allergic reaction, such as rash, itching, swelling (especially of the face, tongue, and throat), dizziness, and difficulty breathing.

Book an appointment with your doctor or pharmacist via Smarter Health to find out more about the recommended dosage for Gentamicin and its proper use based on your condition. Smarter Health allows you to access healthcare services and facilities whenever you need them. Contact Smarter Health now.

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